Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. Product Name: Microcrystalline Cellulose 1.2. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O Chemical Formula: (C6H10O5)n 1.4. EMCOCEL XLM 90. Page 1 of 8. 4 0 obj All Rights Reserved. . MATERIAL SAFETY DATA SHEET. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . Learn about FMC's industry leading goal of net-zero emissions by 2035. >> METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. PDF (28.38 mb) 2022 Corporate Fact Sheet. Chemical Formula: (C6H10O5)n 1.4. 2021 Annual Report. (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. Revision No. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . Micro Crystalline Cellulose. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe SCMm_>x^O9l (n. It is also used in plaque assays for counting. Synergies to simplify formulation challenges and reduce operational costs. 1.3. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. Hi, let us know if you have any questions as you visit our website. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? Aqueous suspensions of microcrystalline cellulose have . No. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . /MediaBox [0 0 612 792] They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. w !1AQaq"2B #3Rbr Created Date: 2/10/2020 8:51:41 PM . From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. MSDS Ref. Meet our leadership team. Validity Area. : 5. %PDF-1.5 ( In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. The short-term limit for total inhalable dust is 20 mg/m3. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. SUBSTANCE IDENTIFICATION 1.1. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. It . Microcrystalline Cellulose. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. Some substance identifiers may have been claimed confidential, or may . Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. 1 0 obj 2 0 obj : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . INCI. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. Production of Pharmaceutical Grade Microcrystalline Cellulose. }o]X4]. ( endobj Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. q86@on$^X_HuH;3` Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Request media, explore upcoming events and read our latest updates. Protect them from sunshine or rain. Revision No. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. ( It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) xv}O2' H~KEe9>G/,:9\i Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. (Microcrystalline Cellulose Market Pr. A family of polysaccharide products that allow distinctive drug delivery solutions. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no /Type/Page It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. Have an order or account question? undefined. Quick Links. PharmaCentral 2021 . <> CoA. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. /Resources 2 0 R GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. Have an order or account question, find answers in our Online Support articles. endobj Truly distinctive drug delivery solutions. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER Earth Supplied Products LLC. The figure below illustrates the structural organisation of cellulose within plants. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. pH 6.0 to 8.0 . Home. Performing this action will revert the following features to their default settings: Hooray! Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. Apply today! SDS - Safety Data Sheet. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. LOT #: Available upon request. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. G2W4de=u183KGH{ vQ#4:1\wc Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * : 9004-34-6 Date Approved: 01/31/2008 . It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. % The data shown below apply only to Avicel PH 101. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. 3 0 obj : 1. Avicel PC 611 Microcrystalline Cellulose. The table below shows the most common physicochemical parameters of this raw material. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. Superior Performance: Provides excellent water uptake and rapid swelling . % endobj "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC B;vLZpHU%ChUyD+[ It is available in different grades and particle sizes. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. %PDF-1.4 (&E. FMC Corporation. Product Name Cellulose microcrystalline. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. . P}MFbN#[>r(y However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? FMC, JRS and Mingtai were estimated to hold for . Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. CAS #: 9004-34-6 << Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. Browse Avicel PH-101 and related products at MilliporeSigma. Microcrystalline cellulose -The oldest polymer finds new industrial uses,. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. Regulatory Information . Product and Company Identification . Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. <> Avicel PC 611 (FMC Biopolymer) . stream Microcrystalline Cellulose E460 MSDS 1. PDF (2.77 mb) 2021 FMC Sustainability Report. Are you looking for information about products and services by region? The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. stream Avicel PH-101. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b 51395-75-6 Avicel RC 591. Avicel Microcrystalline Cellulose Physical Properties. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. No. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Watch Now. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. Wu, K. Zuurman, H.W. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. MATERIAL SAFETY DATA SHEET Version: 1.0 1. Well-recognized product that can do it all. POLYOX resins are nonionic polyethylene oxide solubility polymers. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P All Rights Reserved. EINECS #: 232-674-9 1.7. endobj Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. 130. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. BIOACCUMULATIVE POTENTIAL Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. Fiber supplements can lessen the absorption of some . {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . It is also inert and biocompatible. MCC helps in the formation of spheres because of its . The aqueous solution to barrier membrane coating. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. << The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. 102331. Battista, O. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. Learn about FMC's differentiated biologically-based crop solutions. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? It works as a moisture sponge and permits the controlled growth of spheroids. Manufactured by: China . DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. *r_ *?~4$ &0Y# FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. endobj )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. << Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ q9;v80 <> (1962). Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. <> 0.25 - 0.37. 6 0 obj Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. ChemicalBook. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. Biologicals by FMC. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . SUBSTANCE IDENTIFICATION 1.1. Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. % >> Explore how you can develop your career and bring your creative ideas to life at IFF. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. 0.25 - 0.37. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. Looking for FMC'searnings news? It is hygroscopic and insoluble in water. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Product Name: Microcrystalline Cellulose E460 1.2. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. There may be more fiber in your food than you realized. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . No. Synonyms: Cellulose, Cellulose powder, Cotton linters. No. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . lH5JWy}DgKRR"Fs Eur., JPE . No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . We are artists at heart and creators by nature. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. Safety Data Sheet (SDS) Viewer. Alginates also function as actives in some anti-reflux products. Microcrystalline Cellulose (MCC) MSDS 1. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . Manufacturer: FMC BioPolymer. An agricultural sciences company. A., and Smith, P. A. There have always been two different points of view for the liquidity of MCC. Microcrystalline Cellulose NF. In 1964 FMC, Corporation . Test Data Available. Trademarks: Avicel PH-102. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. endobj Your file is uploaded and ready to be published. Document(s): certificate data msds. 8 0 obj However, consumption of large quantities of the material may have a laxative effect. PDF (4.11 mb) Footer menu 1. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. Thus, Avicel contributes no or very few calories to the food system. : 160182. Avicel RC-591 & CL-611 - Description. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . The most. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization.