A place for patients and relatives. I'm just saying the evidence presented in this article isn't very strong, and more study is needed to show Synthroid causes lung cancer. [2] Meng R, Tang HY, Westfall J, London D, Cao JH, Mousa SA, Luidens M, Hercbergs A, Davis FB, Davis PJ, et al: Crosstalk between integrin v3 and estrogen receptor- is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. (They noted that this age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers). undefined will no longer be visible to you including posts, replies, and photos. I'm not saying that there Is no link between Synthroid and lung cancer. Clin Cancer Res 2011, 30:77. En 3 minutos recibirs en tu email COMPLETAMENTE GRATIS todo lo que necesitas para aumentar las ventas de tu empresa. They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. [2], The observation that patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. Keri Topouzian, D.O. Physician/Author - Facebook Is that what releases free radicals? 1 The number of individuals with thyroid disorders is expected to continue to grow, having reached approximately 750 million globally in 2012. It is very tormenting (for me anyhow) to not know why I got this disease. They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. Eventually, the decline in thyroid hormone production can result in any of the following: Fatigue and sluggishness. Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. I very much appreciate the information you shared. El almacenamiento o acceso tcnico es estrictamente necesario para el propsito legtimo de permitir el uso de un servicio especfico explcitamente solicitado por el abonado o usuario, o con el nico propsito de llevar a cabo la transmisin de una comunicacin a travs de una red de comunicaciones electrnicas. There is also compelling research indicating that desiccated thyroid extract (Armour thyroid) results in superior clinical outcomes versus the synthetic hormone, especially as concerns improved body weight. I bet in the previous discussion, if there was one, we would have concluded it was likely that it was because people are generally not put on enough levothyroxine. Hashimoto's disease progresses slowly over the years. Results indicate that treatment with levothyroxine was linked with significantly increased mortality (hazard ratio = 1.19). Log In. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer Posted on: Monday, August 12th 2013 at 7:15 am Written By: Sayer Ji, Founder A new study has. Is Drug-Based Medicine a Form of Human Sacrifice? Symptoms can include fatigue, shortness of breath with exercise, and decreased ability to exercise. Furthermore, the geometric expansion of hypothyroidism cases in the past decade only thinly conceals an agenda to promote the synthetic form of T4 known as levothyroxine sodium (trade name Synthroid), since with each new disease case the patient is converted into a lifelong customer. [8] van Doorn J, Roelfsema F, van der Heide D: Concentration of thyroxine and 3,5,3'-triiodotyronine in several rat tissue in vivo: the effect of hypothyroidism. They found no significant correlation between T4 sales and breast, colorectal and gastriccancers, but did find a significant correlation for lung cancer (p < 0.05) corrected forsmoking and age. Once I got on the medication, the symptoms disappeared. [15] [16]There is also the more logical option of support the bodys thyroid-hormone producing capabilities using the thyroxine precursor L-tyrosine, a basic amino acid with a relatively high margin of safety. Brit Med J 1978, 1:210212. Endocrinology 2008, 149:22412250. Factors found to be associated with mortality were age, senile dementia, congestive heart failure, chronic renal failure, and a history of cerebrovascular disease. Privacy Policy. Millions Treated For Hypothyroidism At Risk For Lung Cancer Why not simply call it selenium deficiency? Join the Patient & Caregiver Network. Monaldi Arch Chest Dis 2003, 59:140145. If it's high, the test is done again, along with a blood test for the thyroid hormone T-4. This relatively symptom-free reservoir of 'hypothyroid' cases provides a veritable gold mine of potential office visits, billable services and drug prescriptions. They only reappear when I need to fine tune the medication. Article published in Wakeup-World.Com. Hypothyroidism can also lead to swelling of the tongue, hoarse voice, and sleep apnea. Study: Millions Treated for Hypothyroidism At R - Thyroid UK May be of interest: Study: Millions Treated for Hypothyroidism At Risk The great open sky of imagination: for those who u Fermented Foods: Top 8 Reasons to Eat Them. There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a TSH suppressor. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic self-fulfilling prophecy if you will. With the recent announcement by a National Cancer Institute commissioned expert panel that a variety of so-called 'indolent' neoplasms such as ductal carcinoma in situ (DCIS) and high-grade prostatic intraepithelial neoplasia (HGPIN), formerly understood to be forms of breast and prostate cancers, respectively, should be renamed to reflect their intrinsic benignity, a veritable sea change is occurring within the conventional medical establishment. Acta Endocrinol 1988, 118:460464. If people do not wish to find out all they can about their disease that is fine too. [10] Hofer T, Desbaillets I, Hpfl G, Wenger RH, Gassmann M: Characterization of HIFD-1 alpha overexpressing Hela cells and implication for gene therapy. Overtreatment, of course, is the hallmark danger of overdiagnosis. She wrote about a product called Thyrtophin PMG. This is a news report of the research, so I can't learn the details of how the science was conducted. Savvy Senior: Could you have a thyroid problem and not even know it? I read somewhere about the work done many years ago which was mistakenly read and accepted 28 y/o F Low levels across the board for TSH, T3, and T4, Acid reflux drug linked to more than doubled risk of stomach cancer study, thyroiduk.org - further-reading - thyroid-diagnosis-and-treatment. "Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)". Assessment of oxidative stress and its balance has not been taken into consideration up to now as it should be.". The aim of the study was to assess the occurrence and nature of immune-related endocrine adverse events (irAEs) among patients with non-small-cell lung cancer (NSCLC) treated with nivolumab. The authors did not study whether individuals who took Synthroid actually developed lung cancer later in life. Objectives: To examine site-specific cancer incidence and mortality and to evaluate the radiation dose-response association after RAI treatment for hyperthyroidism. Also, what is oxidised stress??? I invite those interested to read it and perhaps we can have a discussion on this study. Millions of people who were not only wrongly diagnosed with cancers and subsequently aggressively treated for them with chemotherapy, radiation and surgery, are now being told that they would have been better left undiagnosed and untreated. Sub-laboratory hypothyroidism and the empirical use of Armour thyroid.Altern Med Rev. Kelly Mellott LinkedIn: Nodify Lung: Nodule Risk Assessment | Biodesix The omnipresent environmental contaminant perchlorate, an ingredient in jet fuel, is also a primary cause of hypothyroidism, but is almost never tested for by the conventional endocrinologists in their patient evaluations. As I have lung cancer and just recently was diagnosed hypothyroidI am very interested as to what you have to say about this connection.your personal insight and any books, websites would be appreciated.you may email me if you prefer. [9] [10] [11] Although we should never forget that LT4 is a life-saving thyroid hormone replacement, and that one should not exclude that the pathological reason that leads to the prescription of LT4 could favor the lung cancer development also. I will respond more later onBut I will briefly say I was on Synthyroid from 1993 to 2011. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. Symptoms. It's possible, for instance, that the reason both sales of Synthroid and the incidence of lung cancer increased is due to an environmental condition that affected both the thyroid and the lungs. Is so taking anti oxidants might be an idea. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: [I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. I wonder if only t3 treatments are preferable than t4 and t3 ? In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. My Endocrinologist was, and continues to be, open about the elevated risk for thyroid cancer due to the multiple. For more, visitGreenMedInfo.comand Facebook.com/GreenMedInfo, or sign up forGreenMedInfos free e-Newsletter. J Endocrinol Invest. Do endocrine adverse events predict longer progression-free survival 2 Hypothyroidism is the most common type of thyroid disorder, and women's risk of hypothyroidism is five to eight times higher than that of . Biomedicine today is awash in controversy associated with the overdiagnosis and overtreatment of asymptomatic populations. The estimated 2.3 million new cases indicate that 1 in every 8 cancers diagnosed in . The article also stresses that too many people are being given the diagnosis of either hypo or hyperthyroidism. [1] Hercbergs AH, Ashur-Fabian O, Garfield D: Thyroid hormone and cancer: clinical studies of hypothyroidism in oncology. 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Biomedicine today is awash in controversy associated with the overdiagnosis and overtreatment of asymptomatic populations. Whether it should be treated remains controversial. Overtreatment, of course, is the hallmark danger of overdiagnosis. elevated TSH, without actually improving the overall physiological situation, nor the patient's subjective experience of well being. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: "[I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. Very interesting article, thank you for sharing. Si as lo deseas puedes revisar el resto de nuestros contenidos para encontrar lo que buscabas o directamente utilizar nuestro buscador. Increased sleepiness. I wish I could say that my story was atypical. [2] Meng R, Tang HY, Westfall J, London D, Cao JH, Mousa SA, Luidens M, Hercbergs A, Davis FB, Davis PJ, et al: Crosstalk between integrin v3 and estrogen receptor- is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. Respiratory function in thyroid disease - UpToDate For more information, please see our I am having a lot of trouble making any sense of this study. Hypothyroidism can cause depression and, without treatment, the symptoms intensify and directly affect the mental state. PMID: 11929079, [15] Thanh D Hoang, Cara H Olsen, Vinh Q Mai, Patrick W Clyde, Mohamed K M Shakir. Comp Biochem Physiol C Toxicol Pharmacol 2002, 133:475481. Considering that the population in Italy is about 60 million people and the sales of LT4 in the country in 2010 were 17.69 million boxes (+ 6% Vs 2009), hypothyroidism, which is the main reason for the prescription, should be a real national concern (almost 0.7 boxes/women/year). Post [5]Wawrzynska L, Sakowicz A, Rudzinski P, Langfort R, Kurzyna M: The conversion to triiodothyronine in the lung: comparison of activity of type I iodotironine 5 deiodinase in lung cancer with peripheral lung tissues. The American Lung Association connects patients, families, friends and caregivers for support and inspiration as they face lung cancer. [8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. The very concept of "marketing" is at odds with the real nature of these materials, which has to do with the protection and expansion of our nature and potential. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic 'self-fulfilling prophecy' if you will. Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. Hypothyroidism reduces respiratory drive and can cause obstructive sleep apnea or pleural effusion, while hyperthyroidism increases respiratory drive and can cause dyspnea on exertion. I do not believe in random events, of nature or otherwise. Scan this QR code to download the app now. There are several books out there written about the topic. Thyroid disease is a major public health concern worldwide. Levothyroxine and cancer risk study : Hi sorry to - Thyroid UK [7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. It took over five years before the someone figured out my ongoing symptoms were due to hypothyroidism. The Dangers of Tylenol: Is it Time to for the FDA Chile: Psychiatrist Leads Crusade To Legalize Mari 13 Things Sure To Slow Down Your Metabolism. In fact, a 2004 study in subjects with normal thyroid function found that administration of tyrosine leads to a significant reduction in serum TSH and improvement in mood in winter compared with placebo, while the combined synthetic T4-T3 supplement leads to a worsening of mood in summer and no improvement in winter, indicating supporting glandular function is superior to replacement therapy, as well as the role seasonality may play in hormone function and hormone treatment interventions. Garlic Beats Drug in Detoxifying Lead Safely From How Yoga and Acupuncture Enhance HealthNew Resear Health Nuts: Seeds And Nuts You Should Eat Every Day. millions treated for hypothyroidism at risk for lung cancer BUT, this is the first I have heard of the potential risk of lung cancer in those who take Synthyroid.