Policy. Clots can form in the veins near your bones that carry a lot of blood (deep veins), a condition called deep vein thrombosis. A prothrombin gene mutation can raise your risk of getting a pulmonary embolism or deep venous thrombosis. That means only one of your parents has to pass the genetic mutation on to you in order for you to inherit it. News-Medical. However, interactions with food, drinks, herbs, and other medications may still occur. But if you have a blood clotting disorder, your blood forms clots more easily than normal. There is no specific "diet" for people with factor V Leiden, but there are foods that can help keep your blood and body healthy, which may reduce your risk of developing a blood clot. But theres no clear consensus, and researchers continue to explore what risks, if any, factor V Leiden poses during pregnancy. THE DOCTORS COULD NOT FIGURE OUT WHERE MY BLOOD CLOTS WERE COMING FROM SINCE I DID NOT HAVE ANY DVT'S. About 1 out of 10,000 people will develop a DVT or PE each year. You may inherit an abnormal Factor II gene from one or both parents. This site complies with the HONcode standard for trustworthy health information: verify here. What are my risks? They may also suspect it if one or more of your biological family members have a history of blood clots. Your doctor can confirm that you have factor V Leiden with a blood test. 1-ranked heart program in the United States. Read below where Experts have answered questions about Factor V Leiden. <]>> Symptoms of deep vein thrombosis in your arm or leg include: Symptoms of a pulmonary embolism (located in your lung) include: It is a genetic mutation in your Factor II gene that makes it create too much prothrombin (coagulation factor II), and you end up with a higher risk of developing blood clots than someone with a normal prothrombin gene. 0000000016 00000 n The 5-Factor Diet is a bundled diet and exercise plan that may help you lose weight and become more active. If you believe The prevalence of factor V Leiden varies by ethnicity. Policy. 2019. But in people who do, these abnormal clots can lead to long-term health problems or become life-threatening. This helps your mood and gives you energy all day long. This can be a life-threatening situation. People with Factor V Leiden make an altered factor V protein as a result of a mutated gene. Want to talk about Multiple Myeloma: Anyone else? According to NutritionData, the best sources of folate per 100 g serving are: Beans and lentils (~50% RDI) Raw spinach (49% RDI) Asparagus (37% RDI) Romaine (Cos) lettuce (34% RDI) Broccoli (27% RDI) Avocado (20% RDI) Oranges/Mangoes (~10% RDI) You may not need to do anything other than lead a healthy lifestyle to minimize the risk of a deep vein thrombosis or pulmonary embolism. What are the chances of passing down the genetic mutation to my children? The exercise portion of the program might have to be changed if you are trying to follow the exercise guidelines of the American Heart Association. If you inherited 1 Factor V Leiden gene from one parent, you have the heterozygous type of Factor V Leiden. But you will have to be very organized and motivated to stay on track. They were hot, red, and huge. Youll spend roughly the same amount on groceries if you keep the bulk of your protein purchases to eggs, lean meats and poultry, and fat-free dairy, as opposed to seafood. News-Medical.Net provides this medical information service in accordance Dont buy ones from the store or wear them without talking to your provider first. Heterozygous Factor V Leiden If you inherited one Factor V Leiden gene from one parent, you have the heterozygous type of Factor V Leiden. 2. If you have this gene mutation, factor V is slow to turn off, and this can create a larger-than-needed clot, which could break off and start traveling through your body. The clotting action of Factor V is controlled by another protein called Activated Protein C. To stop blood from forming clots, Activated Protein C easily turns off Factor V. Activated Protein C does not work as well on the abnormal Factor V Leiden protein. Symptoms of a deep vein thrombosis or pulmonary embolism typically start getting better soon after specific treatment is started. Mayo Clinic does not endorse companies or products. Often, those treatments will require hospitalization. Anticoagulant Food-Drug Interactions - News-Medical.net If your factor V Leiden requires you to take anticoagulant medication, here are some steps that might help you prevent injury and avoid excessive bleeding: Avoid playing contact sports or engaging in other activities that could result in physical injury. Are young and healthy when you get a clot. Tips on transitioning to a whole food fertility diet. When you need health care or go to the hospital, tell your healthcare team that you have Factor V Leiden, so that they can plan the care you need. Mayo Clinic, Rochester, Minn. June 17, 2018. Factor V Leiden is the most common one. For factor V Leiden, some basic questions to ask your doctor include: If your doctor recommends genetic testing, some questions you might want to ask the genetic specialist include: Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. How long will it take to get results back? Research is mixed concerning the weight loss advantage of eating smaller meals more often, but this may have other health benefits. Added sugars in excess of 24 grams per day for people assigned female at birth and 32 grams per day for people assigned male at birth, per the American Heart Association. In: Williams Hematology. It is advised that vitamin K intake through diet (chiefly through liver meats, high amounts of green leafy vegetables, and cranberry juice) also be closely monitored in such patients for the same reason. The two most common hematological diseases the impairment of Factor V causes are Factor V deficiency or Owren's disease, and Factor V Leiden. Advertising revenue supports our not-for-profit mission. Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. However, the disorder raises your risk compared to people without the disorder. On a long flight, take regular walks down the aisles of the plane. You may be treated with blood thinners during this time. This change causes it to resist other proteins that stop excessive clotting. Each 5-Factor five-ingredient meal must include all five must-have food groups: Protein (egg whites, fish, lean meats/poultry, fat-free dairy) Complex carbohydrates (vegetables, sweet potato,. Pruthi RK (expert opinion). If you have the heterozygous type, there is a 50% chance that your child will inherit a Factor V Leiden gene from you. Or maybe youve had no issues, but your loved one needed treatment for DVT. Signs of DVT: swelling or redness of your leg, with pain in your calf or inner thigh, Signs of PE: chest discomfort or shortness of breath. startxref Stand up and walk around during long flights. As a result, too much blood clotting can happen. U.S. National Institutes of Health, National Library of Medicine. Healthy fat (from fish such as salmon, tuna, mackerel, sardines, rainbow trout, or peanut oil, olive oil, canola oil, sunflower oil, Sugar-free drinks (water, sugar-free soda, coffee, tea, or an unsweetened energy drink). With Factor V Leiden the risk of a blood clot increases with age 0 100 200 300 400 500 600 700 800 900 1000 Risk per 100,000 people Childhood 20's 40's 80's Having 1 Factor V Leiden gene (heterozygous type) slightly increases the chance of developing a blood clot. An INR value of 1.1 or below is considered normal in healthy patients, with lower values indicating faster clotting, while higher values show slower clotting rate. That risk is several times higher in homozygous carriers. If signs and symptoms do occur, they can include: Known as a pulmonary embolism, this occurs when a portion of a DVT breaks free and travels through the right side of your heart to your lung, where it blocks blood flow. Zoppi, Lois. Factor V Leiden follows an autosomal dominant inheritance pattern. It does not increase the risk of myocardial infarction (heart attacks) or arterial strokes. You do need treatment with blood thinners if you have had a blood clot or develop one in the future. Symptoms of deep vein thrombosis include: Symptoms of a pulmonary embolism include: If you have symptoms of DVT or a PE, call 911 or your local emergency number. Self-care therapies to support your reproductive health; It even tells you what staples to keep on hand so you will always be able to get a quick meal together. If you get the mutation from one of your parents, you are heterozygous (you have only one abnormal copy of the Factor II gene, but the gene from your other parent is normal). In a healthy individual who is bleeding, platelets and clotting factors or specific proteins form a clot to stop the bleeding. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Retrieved on March 04, 2023 from https://www.news-medical.net/health/Anticoagulant-Food-Drug-Interactions.aspx. Get useful, helpful and relevant health + wellness information. Adults need approximately 1 microgram/kg body weight of vitamin K a day. Bauer KA. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, (https://pubmed.ncbi.nlm.nih.gov/31577252/), (https://www.stoptheclot.org/factor-v-leiden/). Factor V Leiden: Care Instructions | Kaiser Permanente >_IJ9D/\KwrokzHI7lw7B+Vefcr2L`/R6:s#oI`HlG&W|Az_hSafLG*!~?k{Xi|2`7Q\GcLb9'I |./(-k$Bw&uooR`";j$6GKE:t.0V* II'LX2Q074H4bXh. 3&&}o#Rf,M%>i_+23#_~Ub7{1e9O6I@iQ>,L8?@e"XFExot!^>P(@|` 9 ;90{7,N9|Xf@68-VQBaqL8E-u^5iT Id9l'U"ec BW">)W#idirh#Z>w(!($|1Pa_-780 E71>CCJ8VF}mAGLS!qqEb3 1AEd 'DG/syWtbhF#'. https://www.nhlbi.nih.gov/health-topics/venous-thromboembolism. In general, its more common among people who are white in the U.S. and Europe. Eat well. https://rarediseases.info.nih.gov/diseases/6403/factor-v-leiden-thrombophilia. But if you do, prompt treatment can manage your condition. Do you know someone who has suffered a deep vein thrombosis, pulmonary embolism, or other type of venous blood clot? The American Heart Association cites the following as risk factors for blood clots: 5 Symptoms of a Blood Clot You Should Know. Lockwood CJ, et al. The sooner you receive care, the better your chances of a good outcome. The factor V Leiden mutation changes this proteins structure. (accessed March 04, 2023). Cost: Just your groceries. Going on a long flight or a very long road trip. Factor V Leiden makes you more likely to develop: Its important to know that people with factor V Leiden wont necessarily develop DVT or PE. U.S. National Institutes of Health, National Human Genome Research Institute. Most people with factor V Leiden never develop abnormal clots. 2018;43 (5) (Specialty&Oncology suppl):12-15. xb```eB cg`a!OF'96L``XkeWp)8MenQLe*.,j(bicIgBvMS &"T$T'da[[N(~vS$ECp^e ^Ve'/ Chan School of Public Health. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. How frequently do I need to have checkups. Researchers have found that the factor V Leiden mutation involves one small change in the proteins structure. You won't go hungry on The 5-Factor Diet. If you have factor V Leiden, there are other ways you can help reduce your risk of developing a blood clot beyond your diet. Your provider may think you have a clotting problem if you: There is no specific treatment for the mutation itself. Prothrombin G20210A (Factor II Mutation) Resources. If youre having a deep vein thrombosis or pulmonary embolism, your provider will typically treat you with anticoagulants (blood thinners) and occasionally with thrombolytic (clot-busting) medicines. Accessed June 4, 2018. This caution also extends to drug-food interactions. Factor V Leiden: Symptoms, Cause, Diagnosis, and Treatment - WebMD When you are ready, talk with your health care provider for advice and help to stop smoking. Why Am I Still Anemic After Taking Iron Supplements? Mayo Clinic does not endorse companies or products. You should know the warning signs of a problematic blood clot so you can identify it and get help. Results from the PT test are expressed as a ratio called the international normalized ratio (INR). If excess vitamin K is taken, it is stored for future use in the liver. 0000239923 00000 n These blood clots can be life-threatening. One or both of the factor V genes can be mutated and cause the altered form of the factor V protein known as the Factor V Leiden protein to be made. Nothing beats getting vitamins and minerals from food. https://www.uptodate.com/contents/search. This content does not have an English version. Factor V Leiden causes hypercoagulability, which makes it harder for your blood clots to break up. Diseasemaps 2023, FACTORV LEIDEN AND LIVEDOID VASCULOPATHY SURVIVOR. Here's what foods they have in common, and how to build a healthy diet when you have factor V Leiden: 1. However, it is often advised to avoid foods high in Vitamin K. Below is a list of foods that should be avoided because of their . Drink plenty of fluids (without alcohol). These precautions might include: Some precautions to help reduce your risk of blood clots include: If your factor V Leiden requires you to take anticoagulant medication, here are some steps that might help you prevent injury and avoid excessive bleeding: Your doctor may refer you to a specialist in genetic disorders (geneticist) or a specialist in blood disorders (hematologist) for testing to determine whether the cause of your blood clots is genetic and, specifically, whether you have factor V Leiden. Accessed June 4, 2018. 0000229756 00000 n Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. .wpcdt-timer-24806 .wpcdt-clock .wpcdt-digits, Some issues that can be discussed with your doctor include: Other than the increased risk of developing DVT or PE, factor V Leiden may increase the risk of miscarriage or other pregnancy complications, such as preeclampsia and eclampsia, placental abruption (when the placenta separates too early from the wall of your uterus), and having a fetus that grows slower than is usual. Make a donation. Medications can also work differently if they are taken on an empty stomach. Thick blood: Causes, risk factors, symptoms, and treatment Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. With Factor V Leiden the risk of a blood clot increases with age 0 100 200 300 400 500 600 700 800 900 1000 Risk per 100,000 people Childhood 20's 40's 80's Having 1 Factor V Leiden gene (heterozygous type) slightly increases the chance of developing a blood clot. Interactions which affect the efficacy of VKAs may result in bleeding from over-anticoagulation, or thrombosis due to under-anticoagulation. Prothrombin Gene Mutation (Factor II) - Cleveland Clinic Harvard T.H. When you are ready, talk with your health care provider for advice and help to lose weight. The factor V Leiden mutation itself doesnt cause any symptoms. These proteins are essential helpers that support hemostasis. AskMayoExpert. 0000237061 00000 n Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. 4. Still, there is research that suggests that a diet of low GI foods is more likely to cause weight loss, at least in the short term. Deficiencies of Natural Anticoagulants, Protein C, Protein S, and Having additional genetic blood clotting disorders. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2018. endstream endobj 77 0 obj<> endobj 79 0 obj<>/Font<>>>/DA(/Helv 0 Tf 0 g )>> endobj 80 0 obj<> endobj 81 0 obj<>/Font<>/XObject<>/ProcSet[/PDF/Text/ImageC]/ExtGState<>>> endobj 82 0 obj<> endobj 83 0 obj<> endobj 84 0 obj<> endobj 85 0 obj<> endobj 86 0 obj<> endobj 87 0 obj[/ICCBased 102 0 R] endobj 88 0 obj<> endobj 89 0 obj<> endobj 90 0 obj<>stream Otherwise, all your meals should be limited to dishes made with foods from the five must-have groups mentioned above. Most people with this disorder never develop a blood clot. Limited sodium: Get less than 2,300 mg of sodium daily, per the American Heart Association. Your doctor may suspect factor V Leiden if you've had one or more episodes of abnormal blood clotting or if you have a strong family history of abnormal blood clots. Factor V is a protein that is needed for blood to clot properly. Prevention and Treatment of Excessive Blood Clotting (Hypercoagulation). National Library of Medicines list Papillophlebitis Associated With Coexisting Heterozygous Mutations of Clots can form in the veins near your bones that carry a lot of blood (deep veins), a condition called deep vein thrombosis. It is important to discuss potential interactions between existing and new medications to prevent or recognize any side effects. There is no specific treatment for the mutation itself. If you have the homozygous type, your child will inherit a Factor V Leiden gene. . a V@ C= 0000236831 00000 n Do I need to limit my activity in any way? A single copy of these materials may be reprinted for noncommercial personal use only. In this interview, AZoM speaks to Rohan Thakur, the President of Life Science Mass Spectrometry at Bruker, about what the opportunities of the market are and how Bruker is planning on rising to the challenge. Factor V Leiden This results from a genetic change that increases the risk of blood clots, especially in deep veins. Youll prepare and eat five, 5-ingredient meals a day (each takes 5 minutes to prepare) and do 25-minute workouts (consisting of five, 5-minute segments) five times a week. A family history of factor V Leiden increases your risk of inheriting the disorder. Deficiencies of antithrombin and proteins C/S, elevated fibrinogen levels, and other clotting disorders also raise risk. PO Box 825687 Owned and operated by AZoNetwork, 2000-2023. Accessed June 4, 2018. A variety of herbs and vitamins may interact with anticoagulants. These include deep vein thrombosis, factor V Leiden, myocardial infarction, and polycythemia vera, among many others. Is an uncertain result possible, and what would that mean? We use cookies to enhance your experience. Posted May 16, 2017 by Rachael 1000 Good Foods If you have been diagnosed with Factor V Leiden, you should alter your diet to prevent excessive blood clotting. In heterozygous carriers of this mutation, the risk of developing a deep vein thrombosis or pulmonary embolism is about two to three in 1,000. If you are overweight or obese, consider the benefits of losing weight. Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. Factor V Leiden is also known under its other name Factor V Leiden Thrombophilia. .wpcdt-timer-24806 .wpcdt-clock .wpcdt-lbl{color: #ffffff;}.wpcdt-timer-24806 .wpcdt-clock-circle span, If you are homozygous, you will pass the mutation on to your children. Can the results of the test affect my ability to obtain health insurance? If youve had a deep vein thrombosis or pulmonary embolism before and know you have the prothrombin gene mutation, you may need a prescription for low-dose (preventive doses) of an injectable blood thinner (such as heparin or a low-molecular-weight heparin) during your pregnancy and for a few weeks after delivery. Factor V Leiden is a blood clotting disorder. In: Kaushansky K, Prchal JT, Burns LJ, Lichtman MA, Levi M, Linch DC, eds. xref (https://www.heart.org/en/health-topics/venous-thromboembolism/prevention-and-treatment-of-excessive-blood-clotting-hypercoagulation), (https://www.redcrossblood.org/donate-blood/how-to-donate/eligibility-requirements/eligibility-criteria-alphabetical.html), Visitation, mask requirements and COVID-19 information, Heart, Vascular & Thoracic Institute (Miller Family). 0 Here are a few to help you start the conversation: Factor V is a coagulation factor, or protein, in your blood. Some research shows that factor V Leiden impacts pregnancy. If you are heterozygous, theres a 50% chance that your children will get the mutation. A. We do not endorse non-Cleveland Clinic products or services. The mutation in itself is not a reason to avoid donating blood, but you should not give blood if you are using an anticoagulant (blood thinner). Together we can #stoptheclot! Accessed June 4, 2018. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. Exercise regularly for good circulation in the veins of your legs. 0000002579 00000 n Factor V Leiden thrombophilia. One of these factors is Factor V (FV) Leiden (rs6025), which is a missense variant caused by a single nucleotide polymorphism (SNP) in the F5 gene. Follow Canadas Physical Activity Guide. There are many programs, websites and tools that can help you quit. Please use one of the following formats to cite this article in your essay, paper or report: Zoppi, Lois. You inherited one Factor V Leiden gene from your mother and one from your father. Having 2 Factor V Leiden genes (homozygous type) makes the risk much greater . Factor V Leiden and prothrombin gene mutations cause about 50% of inherited coagulopathies. If you or a loved one have factor V Leiden, you might feel scared about what the future will bring. The clot remains in place while other enzymes repair the damaged blood vessel. How long do I need to take the anticoagulant? 0000001914 00000 n About 1 in every 50 white people in Europe and North America has the heterozygous prothrombin gene mutation, making it the second most common inherited clotting disorder. This gene is responsible for aiding in normal blood clotting. The heart-healthy Mediterranean diet which includes lots of fruits and vegetables along with healthy fats is a smart choice for those with factor V Leiden. Creator and celebrity fitness trainer Harley Pasternak says it's a lifestyle plan, not a diet. Wear compression stockings if your provider prescribes them for you. Get useful, helpful and relevant health + wellness information. The factor V Leiden mutation itself doesnt have any specific treatment. Inherited thrombophilias in pregnancy. Yes, those living with factor v Leiden should avoid any foods that contain a high level of vitamin K. (Green leafy vegetables are a big one). This is your bodys reaction to an injury that prevents you from bleeding too much. Advertising on our site helps support our mission. Yes, you may be able to donate blood if youre not taking a blood thinner. Your body has many different proteins that do this work. Healthy fats: Eat healthy fats each day such as olive oil, nuts, seeds and avocado. Try to build up to 150 minutes of moderate-intensity. Your brothers and sisters may have inherited the mutated gene for Factor V Leiden, just like you did. Factor V Deficiency Vs. on this website is designed to support, not to replace the relationship Vitamin K antagonists (VKAs) are the most commonly prescribed oral anticoagulants worldwide. Most notably, you will need to be aware of your vitamin K consumption. 2. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Yes, those living with factor v Leiden should avoid any foods that contain a high level of vitamin K. (Green leafy vegetables are a big one). NBCA provides the information and materials on this site for general information purposes only. It depends on the specific details of the previous deep vein thrombosis or pulmonary embolism. This content does not have an English version. This may not be a good choice for those who have to travel a lot for work, have an inflexible schedule, or prefer to eat out, as food prep and timing may be a problem. Late in my pregnancy I started having horrible swelling in my legs. Accessed June 4, 2018. There needs to be a balance of these proteins to make sure there is just enough clotting power: Factor V is one of the proteins needed to make blood form clots. Factor V Leiden - Diagnosis and treatment - Mayo Clinic In 2010 I was pregnant with my son. Farshchi, H. American Journal of Clinical Nutrition, January 2005. A lot of people carry the genetic mutation and a few people develop blood clots that are related to Factor V Leiden. Keep going to your follow-up appointments with your provider, especially if youre taking a blood thinner. Factor V is a protein or clotting factor that helps create the enzyme reactions that form the fibrin in the clot. Talk to your doctor about your fitness goals before starting this program. The risk increases with age: Having 1 Factor V Leiden gene (heterozygous type) slightly increases the chance of developing a blood clot. Children who are healthy and do not have factor V Leiden will get a blood clot in one out of 50,000-100,000 . Most people with factor V Leiden never develop abnormal clots. It may ease your mind to know that most people with this disorder never have a blood clot. Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. This is why Factor V Leiden is sometimes called Activated Protein C Resistance and why people with this mutation clot more than those without it. What about my children?. Disorder Magnifies Blood Clot Risk - The New York Times The different gene that makes the Factor V Leiden protein is inherited from one or both parents. The NATIONAL BLOOD CLOT ALLIANCE works to advance #bloodclot awareness, prevention, diagnosis, & successful treatments to #stoptheclot. Barbara Woodward Lips Patient Education Center. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Why? Factor V Leiden is an inherited blood clotting disorder that raises your risk of deep vein thrombosis or a pulmonary embolism. 3. https://www.nhlbi.nih.gov/health-topics/venous-thromboembolism. 1, 2 This Cardiology Patient Page will describe deficiencies in the natural anticoagulants, protein C, protein S, and antithrombin that may result in either Should people with Factor V Leiden avoid Vitamin K? Pasternak, H. The 5-Factor Diet, Ballantine Books, 2009. diabetes.org: "Glycemic Index and Diabetes. A genetic mutation (change) causes factor V Leiden. Laboratory testing (blood tests) diagnose this disorder. Anticoagulant Food-Drug Interactions. Kaushansky K, et al., eds. If you want to increase the amount you're eating, your doctor can help you make the adjustment slowly, with appropriate adjustments to your medication. Some people do not have the normal Factor V protein. Advertising on our site helps support our mission. Most people with factor V Leiden never develop abnormal clots. Fortunately, about 95 percent of people with this condition never develop a clot, according to the National Institutes of Health. Regular noncontact exercise, such as walking or swimming, is still recommended for good health. Inheriting two copies one from each parent significantly increases your risk of developing blood clots. 0000000856 00000 n